Effects of multicomponent interventions on biochemical markers in obese youth: a systematic review protocol

Authors

  • Leticia Borfe Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências do Movimento Humano, Porto Alegre, Rio Grande do Sul, Brasil. https://orcid.org/0000-0003-2340-2443
  • Henrique Universidade Federal da Fronteira Sul, Curso de Medicina, Chapecó, Santa Catarina, Brasil. https://orcid.org/0000-0003-4239-0716
  • Cézane Priscila Reuter Universidade de Santa Cruz do Sul, Programa de Pós-Graduação em Promoção da Saúde, Santa Cruz do Sul, Rio Grande do Sul, Brasil. https://orcid.org/0000-0002-4549-3959
  • Caroline Brand Universidade de Santa Cruz do Sul, Programa de Pós-Graduação em Promoção da Saúde, Santa Cruz do Sul, Rio Grande do Sul, Brasil. https://orcid.org/0000-0002-5624-3592
  • José Francisco López Gil Universidade de Murcia, Departamento de Expressão Plástica, Musical e Dinâmica, Faculdade de Educação, Espinardo, Murcia, Espanha. https://orcid.org/0000-0002-7412-7624
  • Javier Brazo-Sayavera Universidade Pablo de Olavide, Departamento de Esportes e Ciência da Computação, Sevilla, Espanha. Universidade de la República, Centro Universitario Regional Noreste, Rivera, Uruguai.
  • Anelise Reis Gaya Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Ciências do Movimento Humano, Porto Alegre, Rio Grande do Sul, Brasil. https://orcid.org/0000-0002-8335-6947

DOI:

https://doi.org/10.12820/rbafs.26e0220

Keywords:

Obesity, Excess weight, Biochemical markers, Youths

Abstract

Physical exercise is effective in modulating circulating inflammatory markers of obesity. However, little is known about the effects of interventions with physical exercise programs accompanied by nutritional and/or psychological guidance, configuring themselves as multicomponent programs. Thus, the aim of this review is to systematically evaluate the evidence related to the effects of multicomponent weight-loss interventions in modulating circulating inflammatory markers in children and adolescents. Therefore, the following databases will be searched to identify all relevant articles: PubMed, SciELO, Lilacs, Web of Science, EMBASE, Scopus, SPORT Discus. Randomized controlled trials and quasi-experimental studies of children and adolescents (6 to 18 years old) will be included. Eligible interventions will target weight-related behaviors (including diet, physical activity, behavior modification and/or combinations thereof). Two independent reviewers will select studies using Rayyan QCRI software and extract the data to a standard form. The main outcomes of the review will be the circulating values of leptin, interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF- α) in a quantitative way. To assess the methodological quality (or risk of bias) of individual studies, Effective Public Health Practice Project assessment tool will be used. The meta-analysis will be performed using the Review Manager software.

Downloads

Download data is not yet available.

References

Pelone F, Specchia ML, Veneziano MA, Capizzi S, Bucci S, Mancuso A, et al. Economic impact of childhood obesity on health systems: A systematic review. Obes Rev. 2012;13(5):431–40.

Nasreddine L, Naja F, Akl C, Chamieh MC, Karam S, Sibai A-M, et al. Dietary, lifestyle and socio-economic correlates of overweight, obesity and central adiposity in lebanese children and adolescents. nutrients. 2014;6(3):1038.

Barragán-Vázquez S, Ariza AC, Ramírez Silva I, Pedraza LS, Rivera Dommarco JA, Ortiz-Panozo E, et al. Pro-Inflammatory Diet Is Associated with Adiposity during Childhood and with Adipokines and Inflammatory Markers at 11 Years in Mexican Children. Nutrients. 2020;12(12):3658.

Castro-Piñero J, Ortega FB, Ruiz JR. Adiposity and cardiovascular risk in children and Adolescents: implications of the amount of fat carried and where. Mayo Clinic Proceedings. 2019;94(10):1928–30.

Muhajarine N, Katapally TR, Fuller D, Stanley KG, Rainham D. Longitudinal active living research to address physical inactivity and sedentary behaviour in children in transition from preadolescence to adolescence. BMC Public Health. 2015;15(1):495.

Koren D, Chirinos JA, Katz LEL, Mohler ER, Gallagher PR, Mitchell GF, et al. Interrelationships between obesity, obstructive sleep apnea syndrome and cardiovascular risk in obese adolescents. Int J Obes. 2015;39(7):1086–93.

Browne NT, Snethen JA, Greenberg CS, Frenn M, Kilanowski JF, Gance-Cleveland B, et al. When pandemics collide: The impact of COVID-19 on childhood obesity. J Pediatr Nurs. 2021;56:90-98.

Han Y, Liu Y, Zhao Z, Zhen S, Chen J, Ding N, et al. Does physical activity-based intervention improve systemic proinflammatory cytokine levels in overweight or obese children and adolescents? Insights from a meta-analysis of randomized control trials. Obes Facts. 2019;12(6):653–68.

Freitas MC, Ceschini FL, Ramallo BT. Resistência à Insulina associada à obesidade: efeitos anti-inflamatórios do exercício físico. Rev Bras Ciência e Mov. 2014;22(3):139–47.

Gorgens SW, Eckardt K, Jensen J, Drevon CA, Eckel J. Exercise and Regulation of adipokine and myokine production. Prog Mol Biol Transl Sci. 2015;135:313–36.

Kasapis C, Thompson PD. The effects of physical activity on serum C-reactive protein and inflammatory markers: A systematic review. J Am Coll Cardiol. 2005;45(10):1563-9.

Mathur N, Pedersen BK. Exercise as a mean to control low-grade systemic Inflammation. Mediators Inflamm. 2008;2008:109502.

Huang Y, Yang Z, Ye Z, Li Q, Wen J, Tao X, et al. Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people. Cardiovasc Diabetol. 2012;11:11.

Tenório TRS, Balagopal PB, Andersen LB, Ritti-Dias RM, Hill JO, Lofrano-Prado MC, et al. Effect of low-versus high-intensity exercise training on biomarkers of inflammation and endothelial dysfunction in adolescents with obesity: A 6-month randomized exercise intervention study. Pediatr Exerc Sci. 2018;30(1):98–107.

Top FÜ, Kaya B, Tepe B, Avci E. Physio-psychosocial and metabolic parameters of obese adolescents: health-promoting lifestyle education of obesity management. community ment health J. 2019;55(8):1419–29.

Wong A, Sanchez-Gonzalez MA, Son WM, Kwak YS, Park SY. The effects of a 12-week combined exercise training program on arterial stiffness, vasoactive substances, inflammatory markers, metabolic profile, and body composition in obese adolescent girls. Pediatr Exerc Sci. 2018;30(4):480–6.

Yetgin MK, Agopyan A, Kucukler FK, Gedikbasi A, Yetgin S, Kayapinar FC, et al. The influence of physical training modalities on basal metabolic rate and leptin on obese adolescent boys. J Pak Med Assoc. 2018;68(6):929–31.

Zguira MS, Slimani M, Bragazzi NL, Khrouf M, Chaieb F, Saïag B, et al. Effect of an 8-week individualized training program on blood biomarkers, adipokines and endothelial function in obese young adolescents with and without metabolic syndrome. Int J Environ Res Public Health. 2019;16(5):751.

Sirico F, Bianco A, D’Alicandro G, Castaldo C, Montagnani S, Spera R, et al. Effects of physical exercise on adiponectin, leptin, and inflammatory markers in childhood obesity: systematic review and meta-analysis. Childhood Obesity. 2018;14:207–17.

Kim ES, Im JA, Kim KC, Park JH, Suh SH, Kang ES, et al. Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth. Obesity. 2007;15(12):3023–30.

Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism. 2007;56(7):1005–9.

Elias RGM, De Farias JP, De Faria WF, Neto AS, Da Silva CC, Rinaldi W. Efeito do exercício físico sobre os marcadores inflamatórios de adolescentes com excesso de peso: Uma revisão sistemática. Rev Educ Fisica. 2015:26(4)633–45.

Hampl S, Odar Stough C, Poppert Cordts K, Best C, Blackburn K, Dreyer Gillette ML. Effectiveness of a Hospital-Based Multidisciplinary Pediatric Weight Management Program: Two-Year Outcomes of PHIT Kids. Child Obes. 2016;12(1):20–5.

Ranucci C, Pippi R, Buratta L, Aiello C, Gianfredi V, Piana N, et al. Effects of an intensive lifestyle intervention to treat overweight/obese children and adolescents. Biomed Res Int. 2017;2017(8573725):1–11.

Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015: Elaboration and explanation. BMJ (Online). 2015;349:g7647.

Thomas BH, Ciliska D, Dobbins M, Micucci S. A process for systematically reviewing the literature: providing the research evidence for public health nursing interventions. Worldviews Evid. Based Nurs. 2004;1(3):176–84.

Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58.

Sterne, JAC, Hernán MA, Reeves BC, Savovic J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355: i4919.

Balshem H, Helfand M, Schünemann HJ, Oxman AD, Kunz R, Brozek J, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64:401-6.

Han TS, Lean ME. A clinical perspective of obesity, metabolic syndrome and cardiovascular disease. JRSM Cardiovasc Dis. 2016;5:204800401663337.

Downloads

Published

2021-07-27

How to Cite

1.
Borfe L, Guerra PH, Reuter CP, Brand C, Gil JFL, Brazo-Sayavera J, et al. Effects of multicomponent interventions on biochemical markers in obese youth: a systematic review protocol. Rev. Bras. Ativ. Fís. Saúde [Internet]. 2021 Jul. 27 [cited 2024 Jul. 3];26:1-8. Available from: https://rbafs.org.br/RBAFS/article/view/14601

Issue

Section

Study Protocols on Physical Activity and Health