Efeitos da suplementação oral de L-arginina na hipotensão pós-exercício de força em indivíduos normotensos: um estudo duplo-cego e cruzado
DOI:
https://doi.org/10.12820/rbafs.31e0443Palavras-chave:
Pressão arterial, Recursos ergogênicos, Óxido nítrico, Exercício de forçaResumo
Introdução: A L-arginina (L-Arg) é precursora essencial na síntese de óxido nítrico (ON) e promove efeitos hipotensores. Contudo, evidências sobre seu papel na hipotensão pós-exercício (HPE) são limitadas, especialmente após exercício de força (EF) em normotensos, dado que as pesquisas existentes priorizam o exercício aeróbio. Objetivo: Investigar se a suplementação oral de L-Arg potencializa a HPE após uma sessão de EF em 12 homens normotensos e inativos fisicamente. Métodos: Os participantes receberam 6 g de L-Arg ou placebo ao término do protocolo de EF (60% de 1RM, 3 séries de 12 repetições) e 30 minutos após, com monitoramento da pressão arterial (PA) por 60 minutos em duas sessões. As análises estatísticas utilizaram ANOVA de medidas repetidas, post hoc de Tukey e teste t de Student (p < 0,05). Resultados: Os participantes apresentaram, na linha de base: 26,5 ± 4,98 anos; 22,8 ± 1,80 kg/m²; PA sistólica e diastólica de 106 ± 5 e 69 ± 9 mmHg, respectivamente. A redução da PA na condição L-Arg foi significativamente maior que no placebo aos 45 e 60 minutos pós-EF (p < 0,05), com reduções máximas de 21,5 ± 8,3 mmHg (sistólica), 11,3 ± 7,2 mmHg (diastólica) e 18,1 ± 8,7 mmHg (média). A concentração plasmática de ON foi significativamente superior aos 60 minutos na sessão com L-Arg (pré: 15,3 ± 1,2 vs. pós: 24,6 ± 3,5 µM/L) em comparação ao placebo (pré: 15,9 ± 3,2 vs. pós: 14,9 ± 0,4 µM/L). Conclusão: A suplementação de L-Arg potencializou a HPE após EF em normotensos, sugerindo seu potencial como intervenção não farmacológica na prevenção primária de doenças cardiovasculares, possivelmente mediada pelo aumento da biodisponibilidade de ON.
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Copyright (c) 2026 Pedro Marques Almeida, Thiago dos Santos Rosa, Deocleciano Ferreira Rios-Neto, Douglas Araujo Vargas, Jessica Mycaelle da Silva Barbosa, Taynah Oliveira Martins, Michel Kendy Souza, Rodrigo Vanerson Passos Neves, Reury Frank Pereira Bacurau, Marcelo Saldanha Aoki, Ronaldo Carvalho Araujo, Hugo de Luca Correa, Alexandre Sérgio Silva, Thomas Caique Cabral Rocha Moraes, Milton Rocha Moraes
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