Como idosas com comprometimento cognitivo lidam com o estressor físico?

Autores

DOI:

https://doi.org/10.12820/rbafs.29e0356

Palavras-chave:

Cortisol, Saliva, Reatividade, Envelhecimento, Exercício

Resumo

O processo de envelhecimento pode promover alterações no eixo hipotálamo-pituitária-adrenal (HPA), causando desregulação nos níveis de cortisol (resposta e recuperação inadequadas) após um estímulo estressor agudo. Para os indivíduos com comprometimento cognitivo leve (CCL), os níveis elevados de cortisol podem estar associados ao estresse crônico apesar de não conhecermos as respostas agudas ao estressor agudo. No entanto, existe uma diferença entre os gêneros e os indivíduos principalmente devido a patologias relacionadas ao envelhecimento como demência ou CCL. O objetivo do trabalho foi comparar o efeito do estressor físico agudo nos níveis de cortisol salivar entre mulheres com CCL e mulheres saudáveis. Foram selecionados idosas com diagnóstico clínico de CCL (n = 8) e idosas saudáveis (n = 10). Ambos os grupos realizaram uma triagem com teste cognitivo e físico. O estressor físico consistiu em uma caminhada de intensidade moderada em esteira por 30 min. O cortisol salivar foi coletado 3 vezes: antes, logo após e 15 minutos após a caminhada. Observou-se redução do cortisol imediatamente após o estressor físico para ambos os grupos com tamanho de efeito grande, porém esses resultados não alcançaram diferença significativa (F = 3,979; p = 0,063). A terceira coleta de cortisol pós 15 minutos mostrou um efeito significativo para o momento (F = 4,075; p = 0,031) com tamanho do efeito grande e redução dos níveis de cortisol. Independente do diagnóstico, as idosas apresentam baixa responsividade do cortisol a um estímulo físico. Apesar disso, os desfechos devem ser interpretados com cautela devidos as limitações.

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Referências

Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos, EG, Kokmen, E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303-08. doi: https://doi.org/10.1001/archneur.56.3.303. DOI: https://doi.org/10.1001/archneur.56.3.303

McEwen BS, Nasca C, Gray JD. Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex. Neuropsychopharmacol. 2016;41(1):3-23. doi: https://doi.org/10.1038/npp.2015.171. DOI: https://doi.org/10.1038/npp.2015.171

Souza-Talarico JN, Chaves EC, Nitrini R, Caramelli P. Chronic stress is associated with high cortisol levels and emotional coping mechanisms in amnestic mild cognitive impairment. Dement Geriatr Cogn Disord. 2009;28(5):465-70. doi: https://doi.org/10.1159/000259696. DOI: https://doi.org/10.1159/000259696

Sapolsky RM, Krey LC, McEwen BS. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev. 1986;7(3):284-301. doi: https://doi.org/10.1210/edrv-7-3-284. DOI: https://doi.org/10.1210/edrv-7-3-284

Gilbertson MW, Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neurosci. 2002;5(11):1242-7. doi: https://doi.org/10.1038/nn958. DOI: https://doi.org/10.1038/nn958

Kudielka BM, Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol Psychol. 2005;69(1):113-32. doi: https://doi.org/10.1016/j.biopsycho.2004.11.009.

Gaffey AE, Bergeman CS, Clark LA, Wirth MM. Aging and the HPA axis: Stress and resilience in older adults. Neurosci Biobehav Rev. 2016;68:928-45. doi: https://doi.org/10.1016/j.neubiorev.2016.05.036. DOI: https://doi.org/10.1016/j.neubiorev.2016.05.036

Stranahan AM, Lee K, Mattson MP. Central mechanisms of HPA axis regulation by voluntary exercise. Neuromolecular Med. 2008;10(2):118-27. doi: https://doi.org/10.1007/s12017-008-8027-0. DOI: https://doi.org/10.1007/s12017-008-8027-0

McEwen BS. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci. 1998;840:33–44. doi: https://doi.org/10.1111/j.1749-6632.1998.tb09546.x. DOI: https://doi.org/10.1111/j.1749-6632.1998.tb09546.x

McEwen BS. Mood disorders and allostatic load. Biol Psychiatry. 2003;54(3):200-7. doi: https://doi.org/10.1016/s0006-3223(03)00177-x. DOI: https://doi.org/10.1016/S0006-3223(03)00177-X

Steckler T, Kalin N, Reul J. Handbook of stress and the brain. Part 1: The neurobiology of stress. Amsterdam: Elsevier science, 2005. DOI: https://doi.org/10.1016/S0921-0709(05)80005-7

Kraemer WJ, Häkkinen K, Newton RU, McCormick M, Nindl BC, Volek JS, et al. Acute hormonal responses to heavy resistance exercise in younger and older men. Eur J Appl Physiol Occup Physiol. 1999;77(3):206-11. doi: https://doi.org/10.1007/s004210050323. DOI: https://doi.org/10.1007/s004210050323

Dalbo VJ, Roberts MD, Hassell SE, Brown RD, Kerksick CM. Effects of age on serum hormone concentrations and intramuscular proteolytic signaling before and after a single bout of resistance training. J Strength Cond Res. 2011;25(1):1-9. doi: https://doi.org/10.1519/JSC.0b013e3181fc5a68. DOI: https://doi.org/10.1519/JSC.0b013e3181fc5a68

Taha MM, Mounir KM. Acute response of sérum cortisol to different intensities of resisted exercise in the elderly. Bull Fac Phys Ther. 2019;24:20-5. doi: https://doi.org/10.4103/bfpt.bfpt_13_18. DOI: https://doi.org/10.4103/bfpt.bfpt_13_18

Paunksnis MR, Evangelista AL, Teixeira CVLS, Alegretti JG, Pitta RM, Alonso AC et al. Metabolic and hormonal responses to different resistance training systems in elderly men. Aging Male. 2018;21(2):106-10. doi: https://doi.org/10.1080/13685538.2017.1379489. DOI: https://doi.org/10.1080/13685538.2017.1379489

Izquierdo M, Laosa O, Cadore EL, Abizanda P, Garcia-Garcia FJ, Hornillos M, et al. Two-Year Follow-up of a Multimodal Intervention on Functional Capacity and Muscle Power in Frail Patients With Type 2 Diabetes. J Am Med Dir Assoc. 2021;22(9):1906-11. doi: https://doi.org/10.1016/j.jamda.2021.06.022. DOI: https://doi.org/10.1016/j.jamda.2021.06.022

Strüder HK, Hollmann W, Platen P, Rost R, Weicker H, Weber K. Hypothalamic-pituitary-adrenal and gonadal axis function after exercise in sedentary and endurance trained elderly males. Eur J Appl Physiol Occup Physiol. 1998;77(3):285-8. doi: https://doi.org/10.1007/s004210050334. DOI: https://doi.org/10.1007/s004210050334

Traustadóttir T, Bosch PR, Matt KS. The HPA axis response to stress in women: effects of aging and fitness. Psychoneuroendocrinology. 2005;30(4):392-402. doi: https://doi.org/10.1016/j.psyneuen.2004.11.002. DOI: https://doi.org/10.1016/j.psyneuen.2004.11.002

Silverman HG, Mazzeo RS. Hormonal responses to maximal and submaximal exercise in trained and untrained men of various ages. J Gerontol A Biol Sci Med Sci. 1996;51(1):B30-7. doi: https://doi.org/10.1093/gerona/51a.1.b30. DOI: https://doi.org/10.1093/gerona/51A.1.B30

Copeland J, Consitt L, Tremblay M. Hormonal responses to endurance and resistance exercise in females aged 19-69 years. J Gerontol Biol Sci. 2002;57(4):B158-65. doi: https://doi.org/10.1093/gerona/57.4.b158. DOI: https://doi.org/10.1093/gerona/57.4.B158

Hötting K, Schickert N, Kaiser J, Röder B, Schmidt-Kassow M. The Effects of Acute Physical Exercise on Memory, Peripheral BDNF, and Cortisol in Young Adults. Neural Plast. 2016;2016:6860573. doi: https://doi.org/10.1155/2016/6860573. DOI: https://doi.org/10.1155/2016/6860573

Hill EE, Zack E, Battaglini C, Viru M, Viru A, Hackney AC. Exercise and circulating cortisol levels: the intensity threshold effect. J Endocrinol Invest. 2008;31(7):587-91. doi: https://doi.org/10.1007/BF03345606. DOI: https://doi.org/10.1007/BF03345606

Kudielka BM, Kirschbaum C. Sex differences in HPA axis responses to stress: a review. Biol Psychol. 2005;69(1):113-32. doi: https://doi.org/10.1016/j.biopsycho.2004.11.009. DOI: https://doi.org/10.1016/j.biopsycho.2004.11.009

Zänkert S, Bellingrath S, Wüst S, Kudielka BM. HPA axis responses to psychological challenge linking stress and disease: What do we know on sources of intra- and interindividual variability?. Psychoneuroendocrinology. 2019;105:86–97. doi: https://doi.org/10.1016/j.psyneuen.2018.10.027. DOI: https://doi.org/10.1016/j.psyneuen.2018.10.027

Kudielka BM, Buske-Kirschbaum A, Hellhammer DH, Kirschbaum C. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender. Psychoneuroendocrinology. 2004;29(1):83-98. doi: https://doi.org/10.1016/s0306-4530(02)00146-4. DOI: https://doi.org/10.1016/S0306-4530(02)00146-4

Krogh J, Nordentoft M, Mohammad-Nezhad M, Westrin A. Growth hormone, prolactin and cortisol response to exercise in patients with depression. J Affect Disord. 2010;125(1-3):189-97. doi: https://doi.org/10.1016/j.jad.2010.01.009. DOI: https://doi.org/10.1016/j.jad.2010.01.009

Beserra A, Oliveira B, Portugal E, Dutra P, Laks J, Deslandes A, et al. Cortisol reactivity in depression and Alzheimer. Dement Neuropsychol. 2022;16(1):61-8. doi: https://doi.org/10.1590/1980-5764-DN-2021-0066. DOI: https://doi.org/10.1590/1980-5764-dn-2021-0066

Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-98. doi: https://doi.org/10.1016/0022-3956(75)90026-6. DOI: https://doi.org/10.1016/0022-3956(75)90026-6

Brucki SM, Malheiros SM, Okamoto IH, Bertolucci PH. Normative data on the verbal fluency test in the animal category in our milieu. Arq Neuro-Psiquiatr. 1997;55(1):56-61. doi: https://doi.org/10.1590/s0004-282x1997000100009. DOI: https://doi.org/10.1590/S0004-282X1997000100009

Ploenes C, Sharp S, Martin, M. Der Uhrentest: Das Zeichnen einer Uhr zur Erfassung kognitiver Störungen bei geriatrischen Patienten [The Clock Test: drawing a clock for detection of cognitive disorders in geriatric patients]. Z Gerontol. 1994;27(4), 246-52.

Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1983;17(1):37-42. doi: https://doi.org/10.1016/0022-3956(82)90033-4. DOI: https://doi.org/10.1016/0022-3956(82)90033-4

Rikli RE, Jones CJ. Senior Fitness Test Manual; Human Kinetics; California State University: Fullerton, CA, USA, 2013.

American College of Sports Medicine. Cálculos metabólicos. In: Manual para o Teste de Esforço e Prescrição do Exercício. 5a ed. Rio de Janeiro: Revinter, 2000.

Borg G. Borg's perceived exertion and pain scales. Human Kinetics, 1998.

Cohen J. Statistical Power Analysis for the Behavioral Sciences, New York, NY: Routledge Academic, 1988.

Otte C, Yassouridis A, Jahn H, Maass P, Stober N, Wiedemann K et al. Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans. J Gerontol A Biol Sci Med Sci. 2003;58(10):B900-5. doi: https://doi.org/10.1093/gerona/58.10.b900. DOI: https://doi.org/10.1093/gerona/58.10.B900

Otte C, Hart S, Neylan TC, Marmar CR, Yaffe K, Mohr DC. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology. 2005;30(1):80-91. doi: https://doi.org/10.1016/j.psyneuen.2004.06.002. DOI: https://doi.org/10.1016/j.psyneuen.2004.06.002

Kiive E, Maaroos J, Shlik J, Tõru I, Harro J. Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(6):1007-13. doi: https://doi.org/10.1016/j.pnpbp.2004.05.035. DOI: https://doi.org/10.1016/j.pnpbp.2004.05.035

Tortosa-Martínez J, Clow A, Caus-Pertegaz N, González-Caballero G, Abellán-Miralles I, Saenz MJ. Exercise Increases the Dynamics of Diurnal Cortisol Secretion and Executive Function in People With Amnestic Mild Cognitive Impairment. J Aging Phys Act. 2015;23(4):550-8. doi: https://doi.org/10.1123/japa.2014-0006. DOI: https://doi.org/10.1123/japa.2014-0006

Hamer M, Steptoe A. Cortisol responses to mental stress and incident hypertension in healthy men and women. J Clin Endocrinol Metab. 2012;97(1):E29-34. doi: https://doi.org/10.1210/jc.2011-2132. DOI: https://doi.org/10.1210/jc.2011-2132

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Publicado

2024-11-22

Como Citar

1.
Beserra AHN, Portugal E da MM, Dutra PML, Dourado MCN, Deslandes AC, Laks J, et al. Como idosas com comprometimento cognitivo lidam com o estressor físico?. Rev. Bras. Ativ. Fís. Saúde [Internet]. 22º de novembro de 2024 [citado 11º de dezembro de 2024];29:1-13. Disponível em: https://rbafs.org.br/RBAFS/article/view/15282

Edição

v. 29 (2024)

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Artigos Originais

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Copyright (c) 2024 Ana Beserra, Patricia Dutra, Eduardo Portugal, Marcia Dourado, Jerson Laks, Andrea Deslandes, Helena Moraes

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