Association between physical activity, cardiometabolic risk factors and vitamin D in children and adolescents: a systematic review

Resumo

Esta revisão sistemática objetivou sintetizar evidências de estudos transversais sobre as associações entre atividade física, fatores de risco cardiometabólicos e concentrações de vitamina D em crianças e adolescentes. A busca foi realizada na PubMed, SciELO, LILACS, Scopus, MEDLINE e SPORTDiscus. No presente estudo, fatores de risco cardiometabólico incluíram obesidade, resistência à insulina, hipertensão arterial sistêmica e alterações desfavoráveis ​​no perfil lipídico (high density lipoprotein baixo, low density lipoprotein e triglicerídeos elevados). Estudos originais com delineamento transversal, publicados entre 2007 e 2019, avaliando a relação entre vitamina D e atividade física e/ou vitamina D e fatores de risco cardiometabólico foram incluídos. No total, quatorze estudos foram selecionados, envolvendo 8340 crianças e adolescentes. Os principais resultados encontrados foram relação inversa significativa entre os níveis de vitamina D e os fatores de risco cardiometabólico. Todos os estudos (n = 8) que testaram a associação entre atividade física e concentrações de 25-hidroxivitamina D (25 (OH) D) mostraram uma relação direta e significativa entre eles.  Além disso, nove dos onze estudos que testaram a associação entre 25 (OH) D e índice de massa corporal apresentaram uma relação inversa e significativa entre 25 (OH) D com obesidade. Conclui-se que concentrações suficientes de vitamina D estão relacionadas a um perfil cardiometabólico mais favorável. Crianças e adolescentes obesos ou insuficientemente ativos têm maior risco de apresentar hipovitaminose D.

Downloads

Não há dados estatísticos.

Referências

Magdalena AD, Lígia AM. Funções plenamente reconhecidas de nutrientes - Vitamina D. ILSI. 2014;2(2):1–24.

Skaaby T. The relationship of vitamin D status to risk of cardiovascular disease and mortality. Dan Med J. 2015;62(2):1–17.

Reis JP, Von Mühlen D, Michos ED, Miller III ER 3rd, Appel LJ, Araneta MR, et al. Serum Vitamin D, parathyroid hormone levels, and carotid atherosclerosis. Atherosclerosis. 2009;207(2):585-90.

Holick MF. Vitamina D. Como um tratamento tão simples pode reverter doenças tão importantes. 1 ed. São Paulo: Editora Fundamento Educacional, 2012.

Magdalena AD. Vitamina D. International Life Sciences Institute do Brasil. 2014;2(2):1–64.

Mohr SB, Garland CF, Gorham ED, Grant WB, Garland FC. Ultraviolet B irradiance and vitamin D status are inversely associated with incidence rates of pancreatic cancer worldwide. Pancreas. 2010;39(5):669-74.

Mohr SB, Gorham ED, Garland CF, Grant WB, Garland FC, Cuomo RE. Are low ultraviolet B and vitamin D associated with higher incidence of multiple myeloma? J Steroid Biochem Mol Biol. 2015;148:245-52.

Gorham ED, Barrett-Connor E, Highfill-Mcroy RM, Mohr SB, Garland CF, Garland FC, et al. Incidence of insulin-requiring diabetes in the US military. Diabetologia. 2009;52(10):2087–91.

Kelishadi R, Salek S, Salek M, Hashemipour M, Movahedian M. Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial. J Pediatr. 2014;90(1):28-34.

Burton JM, Kimball S, Vieth R, Bar-Or A, Dosch HM, Cheung R, et al. A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. Neurology. 2010;74(23):1852-61.

Kelishadi R, Ardalan G, Motlagh ME, Shariatinejad K, Heshmat R, Poursafa P, et al. National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): The CASPIAN-III Study Nutrition. 2014;30(1):33-41.

Moreira C, Moreira P, Abreu S, Santos PC, Moreira-Silva I, Póvoas S, et al. Vitamin D intake and cardiometabolic risk factors in adolescents. Metab Syndr Relat Disord. 2014;12(3):171-8.

Van Schoor NM, Lips P. Worldwide vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80.

Chowdhury R, Taneja S, Bhandari N, Sinha B, Upadhyay RP, Bhan MK, et al. Vitamin-D deficiency predicts infections in young north Indian children: A secondary data analysis. PloS One. 2017;12(3):e0170509.

Van der Meer IM, Middelkoop BJ, Boeke AJ, Lips P. Prevalence of vitamin D deficiency among Turkish, Moroccan, Indian and sub-Sahara African populations in Europe and their countries of origin: An overview. Osteoporos Int. 2011;22(4):1009–21.

Rezende LF, Azeredo CM, Canella DS, Claro RM, de Castro IR, Levy RB, et al. Sociodemographic and behavioral factors associated with physical activity in Brazilian adolescents. BMC Public Health. 2014;14):485.

Maeda SS, Borba VZC, Brasilio M, Silva DMW, Borges JLC, Bandeira F, et al. Recommendations of the Brazilian Society of Endocrinology and Metabology (SBEM) for the diagnosis and treatment of hypovitaminosis D. Arq Bras Endocrinol Metabol. 2014;58(5):411-33.

Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the US adolescent population. Pediatrics. 2009;124(3):371-80.

Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol. 2011;91(2):115-14.

Osmancevic A, Gillstedt M, Landin-Wilhelmsen K, Wennberg Larkö AM, Larkö O, Holick MF, et al. Size of the exposed body surface area, skin erythema and body mass index predict skin production of vitamin D. J Photochem Photobiol B. 2015;149:224-33.

Elizondo-Montemayor L, Ugalde-Casas PA, Serrano-González M, Cuello-García CA, Borbolla-Escoboza JR. Serum 25-hydroxyvitamin D concentration, life factors and obesity in Mexican children. Obesity. 2010;18(9):1805-11.

Cabral M, Araújo J, Teixeira J, Barros H, Martins S, Guimarães JT, et al. Vitamin D levels and cardiometabolic risk factors in Portuguese adolescents. Int J Cardiol. 2016;220:501-8.

Galvão TF, Pansani TSA, Harrad D. Principais itens para relatar Revisões sistemáticas e Meta-análises: A recomendação PRISMA. Epidemiol Serv Saude. 2015;24:335-42.

Hossain MJ, Levinson A, George D, Canas J, Kumar S, et al. Vitamin D status andcardiovascular risk in obesity: effect of physical activity in nonvitamin D supplemented adolescents. Metab Syndr Relat Disord. 2018;16(4):197-203.

Zeitler C, Fritz R, Smekal G, et al. Association Between the 25-Hydroxyvitamin D Status and Physical Performance in Healthy Recreational Athletes. Int J Environ Res Public Health. 2018;15(12):2724.

Orysiak J, Mazur-Rozycka J, Fitzgerald J, Starczewski M, Malczewska-Lenczowska J, et al. Vitamin D status and its relation to exercise performance and iron status in young ice hockey players. PloS One. 2018;13(4):e0195284.

Skalska M, Nikolaidis PT, Knechtle B, Rosemann TJ, Radzimiński Ł, Jastrzębska J, et al. Vitamin D Supplementation and Physical Activity of Young Soccer Players during High-Intensity Training. Nutrients.2019;11(2):349.

Stern RS, Weinstein MC, Baker SG. Risk reduction for nonmelanoma skin cancer with childhood sunscreen use. Arch Dermatol. 1986;122(5):537-45.

Marks R, Jolley D, Lectsas S, et al. The role of childhood exposure to sunlight in the development of solar keratoses and non‐melanocytic skin cancer. Med J Aust. 1990;152(2):62-66.

Telama R, Yang X, Hirvensalo M, Raitakari O. Participation in organized youth sport as a predictor of adult physical activity: a 21-year longitudinal study. Pediatr Exerc Sci. 2006;18(1):76-88.

Kjønniksen L, Anderssen N, Wold B. Organized youth sport as a predictor of physical activity in adulthood. Scand J Med Sci Sports. 2009;19(5): 646-54.

Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. Jama. 2003;290(17):2277-83.

Reis JP, Von Mühlen D, Miller III ER, Michos ED, et al. Vitamin D status and cardiometabolic risk factors in the US adolescent population. Pediatrics.2009;124(3):e371.

Pollock NK, Bernard PJ, Gutin B, Davis CL, Zhu H, et al. Adolescent obesity, bone mass, and cardiometabolic risk factors. J Pediatr. 2011;158(5):727-34.

Ferreira CDS, Maeda SS, Batista MC, Lazaretti-Castro M, Vasconcellos LDS et al. Posicionamento Oficial da Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial (SBPC/ML) e da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)–Intervalos de Referência da Vitamina D-25 (OH) D. Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial. 2018.

Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52(6):377-84.

Strong WB, Malina RM, Blimkie CJ, Daniels SR, Dishman RK, Gutin B, et al. Evidence based physical activity for school-age youth. J Pediatr. 2005;146:732-37.

Vagetti GC, Barbosa Filho VC, Moreira NB, Oliveira VD, Mazzardo O, Campos W.D. (2014). Association between physical activity and quality of life in the elderly: a systematic review, 2000-2012. Braz J Psychiatr. 2014;36(1):76-88.

Absoud M, Cummins C, Lim MJ, Wassmer E, Shaw N. Prevalence and predictors of vitamin D insufficiency in children: A Great Britain population-based study. PLoS One. 2011;6(7):e22179.

Chung SJ, Lee YA, Hong H, Kang MJ, Kwon HJ, Shin CH, et al. Inverse relationship between vitamin D status and insulin resistance and the risk of impaired fasting glucose in Korean children and adolescents: the Korean National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Public Health Nutr. 2014;17(4):795-802.

Valtueña J, Gracia-Marco L, Huybrechts I, Breidenassel C, Ferrari M, Gottrand F, et al. Cardiorespiratory fitness in males, and upper limbs muscular strength in females, are positively related with 25-hydroxyvitamin D plasma concentrations in European adolescents: the HELENA study. QJM. 2013;106(9):809-21.

Dong Y, Pollock N, Stallmann-Jorgensen IS, Gutin B, Lan L, Chen TC, et al. Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitness. Pediatrics. 2010;125(6):1104-11.

Rafraf M, Hasanabad SK, Jafarabadi MA. Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran. Public Health Nutr. 2014;17(4):803-12.

Colao A, Muscogiuri G, Rubino M, Vuolo L, Pivonello C, Sabatino P, et al. Hypovitaminosis D in adolescents living in the land of sun is correlated with incorrect lifestyle: a survey study in Campania region. Endocrine. 2015;49(2):521-8.

Vierucci F, Del Pistoia M, Fanos M, Erba P, Saggese G. Prevalence of hypovitaminosis D and predictors of vitamin D status in Italian healthy adolescents. Ital J Pediatr. 2014;5(40):54.

Rodríguez-Rodríguez E, Ortega RM, González-Rodríguez LG, & López-Sobaler AM. Vitamin D deficiency is an independent predictor of elevated triglycerides in Spanish school children. Eur J Nutr. 2011; 50(5): 373-8.

Nam GE, Kim DH, Cho KH, Park YG, Han KD, Choi YS, et al. Estimate of a predictive cut-off value for serum 25-hydroxyvitamin D reflecting abdominal obesity in Korean adolescents. Nutr Res. 2012;32(6):395-402.

Parikh S, Guo DH, Pollock NK, Petty K, Bhagatwala J, Gutin B, et al. Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American black and white adolescents living in a year-round sunny climate. Diabetes Care. 2012;35(5):1133-41.

Kensarah OA, Jazar AS, Azzeh FS. Hypovitaminosis D in healthy toddlers and preschool children from Western Saudi Arabia. Int J Vitam Nutr Res. 2015;85(1-2):50-60.

Petersen RA, Dalskov SM, Sørensen LB, Hjorth MF, Andersen R, Tetens I et al. Vitamin D status is associated with cardiometabolic markers in 8–11-year-old children, independently of body fat and physical activity. Br J Nutr Title, 2015; 114(10): 1647-55.

Ha CD, Cho JK, Lee SH, Kang HS. Serum vitamin D, physical activity, and metabolic risk factors in Korean children. Med Sci Sports Exerc. 2013;45(1):102-10.

Corazza PRP, Tadiotto MC, Michel DA, Lopes MDF, de Jesus ÍC, Purim KSM & Leite N. Low Levels of Physical Activity are Related to Hypovitaminosis D in Eutrophic Adolescents. J Exerc Physiol Online. 2018;21(3):158-70.

Buffington C, Walker B, Cowan GS Jr, Scruggs D. Vitamin D deficiency in the morbidly obese. Obes Surg. 1993;3(4):421-5.

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690–3.

Tai K, Need AG, Horowitz M, Chapman IM. Vitamin D, glucose, insulin, and insulin sensitivity. Nutrition. 2008;24(3):279–85.

Resnick LM, Muller FB, Laragh JH. Calcium-regulating hormones in essential hypertension. Relation to plasma renin activity and sodium metabolism. Ann Intern Med. 1986;105(5):649–54.

Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49(5):1063-72.

Sugden JA, Davies JI, Witham MD, Morris AD, Struthers AD. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabet Med. 2008;25(3):320-5.

Bouillon R, Carmeliet G, Verlinden L, van Etten E, Verstuyf A, Luderer HF, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008;29(6):726-76.

Lopes MDFA, Bento PCB, Lazarotto L, Rodacki A, Leite, N. Efeitos da caminhada aquática sobre aspectos antropométricos e metabólicos em jovens obesos. Rev Bras Cineantropom Desempenho Hum.2015;2(17):145-55.

Wanner M, Richard A, Martin B, Linseisen J, Rohrmann S. Associations between objective and self-reported physical activity and vitamin D serum levels in the US population. Cancer Causes Control.2015;26(6):881-91.

Abboud M, Rybchyn MS, Rizk R, Fraser DR, Mason RS. Sunlight exposure is just one of the factors which influence vitamin D status. Photochem Photobiol Sci. 2017;16(3):302-13.

Corazza PRP, Tadiotto MC, Michel DA, Lopes MF, Jesus IC, Purim KSM, Leite N. Photoprotection, Solar Exposure and Vitamin D in Active and Sedentary Eutrophic Adolescents. JEP online.2017;20(4):76-87.

Publicado
20-08-2019
Seção
Artigos de Revisão